Publications

Neuroimaging biomarkers of mTOR inhibition on vascular and metabolic functions in aging brain and Alzheimer’s disease

Lee J, Yanckello LM, Ma D, Hoffman JD, Parikh I, Thalman S, Bauer B, Hartz AMS, Hyder F, Lin AL

Front Aging Neurosci.

2018 10:225. doi: 10.3389/fnagi.2018.00225.

Preventing P-gp ubiquitination lowers Aβ brain levels in an Alzheimer’s disease mouse model

Hartz AMS, Zhong Y, Shen AN, Abner EL, Bauer B

Front Aging Neurosci.

2018 10:186. doi: 10.3389/fnagi.2018.00186.

Matrix metalloproteinase-mediated blood-brain barrier dysfunction in epilepsy

Rempe RG, Hartz AMS, Soldner ELB, Sokola BS, Alluri SR, Abner EL, Kryscio RJ, Pekcec A, Schlichtiger J, Bauer B

J Neurosci.

2018 38:4301-15. doi: 10.1523/JNEUROSCI.2751-17.2018.

Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice

Ma D, Wang AC, Parikh I, Green SJ, Hoffman JD, Chlipala G, Murphy MP, Sokola BS, Bauer B, Hartz AMS, Lin AL

Sci Rep.

2018 8:6670. doi: 10.1038/s41598-018-25190-5.

Role of L-type amino acid transporter 1 at the inner blood-retinal barrier in the blood-to-retina transport of gabapentin

Akanuma SI, Yamakoshi A, Sugouchi T, Kubo Y, Hartz AMS, Bauer B, Hosoya KI

Mol Pharm.

2018 15:2327-37. doi: 10.1021/acs.molpharmaceut.8b00179.

Age Drives Distortion of Brain Metabolic, Vascular and Cognitive Functions, and the Gut Microbiome

Hoffman JD, Parikh I, Green SJ, Chlipala G, Mohney RP, Keaton M, Bauer B, Hartz AMS, Lin AL

Front Aging Neurosci.

2017 9:298. doi: 10.3389/fnagi.2017.00298.

Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers

Tang F, Hartz AMS, Bauer B

Front Neurol.

2017 8:301. doi: 10.3389/fneur.2017.00301.

P-gp Protein Expression and Transport Activity in Rodent Seizure Models and Human Epilepsy

Hartz AM, Pekcec A, Soldner EL, Zhong Y, Schlichtiger J, Bauer B

Mol Pharm.

2017 14:999-1011. doi: 10.1021/acs.molpharmaceut.6b00770.

Hitting the BBB

Louie SW, Amgen MS, Bauer B, Ronaldson PT

AAPS Newsmagazine.

April 2017

Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions

Parikh I, Guo J, Chuang KH, Zhong Y, Rempe RG, Hoffman JD, Armstrong R, Bauer B, Hartz AM, Lin AL

Aging (Albany NY).

2016 8:2814-26. doi: 10.18632/aging.101094.

Highlights From the American Association of Pharmaceutical Scientists/ International Transporter Consortium Joint Workshop on Drug Transporters in Absorption, Distribution, Metabolism, and Excretion: From the Bench to the Bedside – Clinical Pharmacology Considerations

Ronaldson PT, Bauer B, El-Kattan AF, Shen H, Salphati L, Louie SW

Clin Pharmacol Ther.

2016 100:419-22. doi: 10.1002/cpt.439.

Matrix metalloproteinases in the brain and blood-brain barrier: Versatile breakers and makers

Rempe RG, Hartz AMS, Bauer B

J Cereb Blood Flow Metab.

2016 36:1481-507. doi: 10.1177/0271678X16655551.

Aβ40 reduces P-glycoprotein at the blood-brain barrier through the ubiquitin-proteasome pathway

Hartz AM, Zhong Y, Wolf A, LeVine H, 3rd, Miller DS, Bauer B

J Neurosci.

2016 36:1930-41. doi: 10.1523/JNEUROSCI.0350-15.2016.

A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice

Wolf A, Bauer B, Abner EL, Ashkenazy-Frolinger T, Hartz AM

PLoS One.

2016 11:e0147733. doi: 10.1371/journal.pone.0147733.

The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1

Akkaya BG, Zolnerciks JK, Ritchie TK, Bauer B, Hartz AM, Sullivan JA, Linton KJ

Mol Membr Biol.

2015 32:39-45. doi: 10.3109/09687688.2015.1023378.

ABC Transporters and the Alzheimer’s Disease Enigma

Wolf A, Bauer B, Hartz AM

Front Psychiatry.

2012 3:54. doi: 10.3389/fpsyt.2012.00054.

Amyloid-β contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy

Hartz AM, Bauer B, Soldner EL, Wolf A, Boy S, Backhaus R, Mihaljevic I, Bogdahn U, Klunemann HH, Schuierer G, Schlachetzki F

Stroke.

2012 43:514-23. doi: 10.1161/STROKEAHA.111.627562.

The Blood-Brain Barrier in Epilepsy

Bauer B, Schlichtiger J, Pekcec A, Hartz A

In: Afawi Z, editor. Clinical and Genetic Aspects of Epilepsy

2011 London, UK: IntechOpen; p. 23-54. doi: 10.5772/21561

Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels

Jacob A, Hartz AM, Potin S, Coumoul X, Yousif S, Scherrmann JM, Bauer B, Decleves X

Fluids Barriers CNS.

2011 8:23. doi: 10.1186/2045-8118-8-23.

Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team up

Agarwal S, Hartz AM, Elmquist WF, Bauer B

Curr Pharm Des.

2011 17:2793-802. doi: 10.2174/138161211797440186.

Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters

Shukla S, Skoumbourdis AP, Walsh MJ, Hartz AM, Fung KL, Wu CP, Gottesman MM, Bauer B, Thomas CJ, Ambudkar SV

Mol Pharm.

2011 8:1292-302. doi: 10.1021/mp2001022.

Engaging neuroscience to advance translational research in brain barrier biology

Neuwelt EA, Bauer B, Fahlke C, Fricker G, Iadecola C, Janigro D, Leybaert L, Molnar Z, O'Donnell ME, Povlishock JT, Saunders NR, Sharp F, Stanimirovic D, Watts RJ, Drewes LR

Nat Rev Neurosci.

2011 12:169-82. doi: 10.1038/nrn2995.

ABC transporters in the CNS – an inventory

Hartz AM, Bauer B

Curr Pharm Biotechnol.

2011 12:656-73. doi: 10.2174/138920111795164020.

Regulation of ABC transporters at the blood-brain barrier: new targets for CNS therapy

Hartz A, Bauer B

Molecular interventions.

2010 10:293.

Estrogen receptor β signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein

Hartz AM, Madole EK, Miller DS, Bauer B

J Pharmacol Exp Ther.

2010 334:467-76. doi: 10.1124/jpet.110.168930.

Targeting regulation of ABC Transporters at the Blood-Brain Barrier to improve Pharmacotherapy of CNS Disorders

Bauer B

International Drug Discovery.

2010:76-9.

Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer’s disease

Hartz AM, Miller DS, Bauer B

Mol Pharmacol.

2010 77:715-23. doi: 10.1124/mol.109.061754.

17-β-Estradiol: a powerful modulator of blood-brain barrier BCRP activity

Hartz AM, Mahringer A, Miller DS, Bauer B

J Cereb Blood Flow Metab.

2010 30:1742-55. doi: 10.1038/jcbfm.2010.36.

Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation

Pekcec A, Unkruer B, Schlichtiger J, Soerensen J, Hartz AM, Bauer B, van Vliet EA, Gorter JA, Potschka H

J Pharmacol Exp Ther.

2009 330:939-47. doi: 10.1124/jpet.109.152520.

Signaling to P-glycoprotein-A new therapeutic target to treat drug-resistant epilepsy?

Hartz AM, Notenboom S, Bauer B

Drug News Perspect.

2009 22:393-7. doi: 10.1358/dnp.2009.22.7.1401354.