Publications

Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR

Ott M, Fricker G, Bauer B

J Pharmacol Exp Ther.

2009 329:141-9. doi: 10.1124/jpet.108.149690.

Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice

Shukla S, Zaher H, Hartz A, Bauer B, Ware JA, Ambudkar SV

Pharm Res.

2009 26:480-7. doi: 10.1007/s11095-008-9735-8.

Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition

Zibell G, Unkruer B, Pekcec A, Hartz AM, Bauer B, Miller DS, Potschka H

Neuropharmacology.

2009 56:849-55. doi: 10.1016/j.neuropharm.2009.01.009.

Novel and emerging strategies in drug delivery for overcoming the blood-brain barrier

Stenehjem DD, Hartz AM, Bauer B, Anderson GW

Future Med Chem.

2009 1:1623-41. doi: 10.4155/fmc.09.137.

Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy

Miller DS, Bauer B, Hartz AM

Pharmacol Rev.

2008 60:196-209. doi: 10.1124/pr.107.07109.

Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling

Bauer B, Hartz AM, Pekcec A, Toellner K, Miller DS, Potschka H

Mol Pharmacol.

2008 73:1444-53. doi: 10.1124/mol.107.041210.

Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier

Hartz AM, Bauer B, Block ML, Hong JS, Miller DS

Faseb Journal.

2008 22:2723-33. doi: 10.1096/fj.08-106997.

Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier

Bauer B, Hartz AM, Lucking JR, Yang X, Pollack GM, Miller DS

J Cereb Blood Flow Metab.

2008 28:1222-34. doi: 10.1038/jcbfm.2008.16.

Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier

Bauer B, Hartz AM, Miller DS

Mol Pharmacol.

2007 71:667-75. doi: 10.1124/mol.106.029512.

In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation

Bauer B, Yang X, Hartz AM, Olson ER, Zhao R, Kalvass JC, Pollack GM, Miller DS

Mol Pharmacol.

2006 70:1212-9. doi: 10.1124/mol.106.023796.

Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide

Hartz AM, Bauer B, Fricker G, Miller DS

Mol Pharmacol.

2006 69:462-70. doi: 10.1124/mol.105.017954.

Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1

Hartz AM, Bauer B, Fricker G, Miller DS

Mol Pharmacol.

2004 66:387-94. doi: 10.1124/mol.104.001503.

Drug delivery across the blood-brain barrier

Hartz AMS, Bauer B, Baehr CH, Miller DS, Fricker G

Curr Nanosci.

2005 1:203-9. doi: 10.2174/157341305774642948.

Modulation of p-glycoprotein transport function at the blood-brain barrier

Bauer B, Hartz AMS, Fricker G, Miller DS

Exp Biol Med.

2005 230:118-27. doi: 10.1177/153537020523000206

Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier

Bauer B, Hartz AM, Fricker G, Miller DS

Mol Pharmacol.

2004 66:413-9. doi: 10.1124/mol.66.3.

Compound profiling for P-glycoprotein at the blood-brain barrier using a microplate screening system

Bauer B, Miller DS, Fricker G

Pharm Res.

2003 20:1170-6. doi: 10.1023/a:1025040712857.

Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

Fellner S, Bauer B, Miller DS, Schaffrik M, Fankhanel M, Spruss T, Bernhardt G, Graeff C, Farber L, Gschaidmeier H, Buschauer A, Fricker G

J Clin Invest.

2002 110:1309-18. doi: 10.1172/JCI15451.

Ivermectin excretion by isolated functionally intact brain endothelial capillaries

Nobmann S, Bauer B, Fricker G

Br J Pharmacol.

2001 132:722-8. doi: 10.1038/sj.bjp.0703762.

Publications

Novel and emerging strategies in drug delivery for overcoming the blood-brain barrier

Modulation of p-glycoprotein transport function at the blood-brain barrier

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