Neurovascular deficits and blood-brain barrier (BBB) dysfunction are major hallmarks of brain trauma and neurodegenerative diseases. Oxidative stress is a prominent contributor to neurovascular unit (NVU) dysfunction and can propagate BBB disruption. Oxidative damage results in an imbalance of mitochondrial homeostasis, which can further drive functional impairment of brain capillaries. To this end, we developed a method to track mitochondrial-related changes after oxidative stress in the context of neurovascular pathophysiology as a critical endophenotype of neurodegenerative diseases.
Hady presents at the Trainee Research Day
Hady presented a poster on anti-amyloid antibodies and their effects on blood-brain barrier integrity at the College of Medicine Trainee Research Day. This work represents a new and timely research direction in the lab that aligns with the development of novel disease-modifying antibody therapeutics for Alzheimer’s disease.
March 23, 2026
