Atcharaporn’s New Paper “N-Acetylcysteine Attenuates Aβ-Induced Oxidative Stress, Barrier Disruption, and Renal Dysfunction in 5xFAD Mice” is Published
Oxidative stress contributes to blood–brain barrier leakage, renal dysfunction, and cognitive decline in Alzheimer’s disease. In this study, the team used 5xFAD mice to show that N-acetylcysteine (NAC) reduces Aβ-induced oxidative damage and improves cognition and organ function. Congratulations Atcharaporn and team! View publication
Farwell Lunch for Atcharaporn and Ramtin
We celebrated Atcharaporn and Ramtin for their amazing work and dedication over the past two years in the lab with a going-away lunch at KPOT. Thank you both for everything—you will be missed, and we’re excited to see where your next chapters take you!
Anika Presents at AD/PD2025
Anika attended the AD/PD2025 conference in Vienna, Austria, where she co-chaired the session “Cerebrovascular Changes, CAA, BBB” alongside Dr. Shinobu Kitazume. She was also invited to present our recent work titled “Blood-Brain Barrier Dysfunction in Alzheimer’s Disease with Epilepsy: New Mechanistic Insights and Therapeutic Strategies.”
Anika Presents at ABC2025
Anika has been invited to give a talk titled “Blood-Brain Barrier Dysfunction in Alzheimer’s Disease: An Environmental Health Perspective” at the ABC2025 meeting in Innsbruck, Austria, on March 2. The ABC2025 meeting brings together leading scientists from around the world to discuss the latest advancements in ABC transporter proteins, covering both basic and applied aspects.
Atcharaporn’s Perfect Bradford Assay
BHL proudly celebrates Atcharaporn’s perfect Bradford with a team pizza party! This long-standing tradition has remained a rare achievement, with only a few members reaching this high standard— the last in 2020. Atcharaporn’s achievement is even more special as she is the first in the lab to reach this milestone with a sample! We look […]
BHL Participates in Lexington Polar Plunge
The BHL team takes the plunge at the Lexington Polar Plunge! The team fundraised a total of $1,308 for Special Olympics Kentucky, which supports individuals with intellectual disabilities. This tradition started back in 2011 when the lab, then located in Minnesota, joined nearly 900 participants in the Polar Bear Plunge and jumped into the below […]
New Paper Published: Fluorescence-Guided Resection of GL261 Red-FLuc and TRP-mCherry-FLuc Mouse Glioblastoma Tumors
View a brief summary of the paper in video format! Do You Know the Two Luciferase-Expressing Mouse Glioblastoma Models? | Encyclopedia MDPI Neurovascular deficits and blood-brain barrier (BBB) dysfunction are major hallmarks of brain trauma and neurodegenerative diseases. Oxidative stress is a prominent contributor to neurovascular unit (NVU) dysfunction and can propagate BBB disruption. Oxidative […]
New Paper Published: Synergistic Effects of Plasma S100B and MRI Measures of Cerebrovascular Disease on Cognition in Older Adults
Our collaborative work with Dr. Gold and his team underscores the potential of combining blood biomarkers and brain imaging to identify early signs of vascular contributions to cognitive decline. By measuring levels of S100b, an indirect marker of blood-brain barrier leakage, and pairing it with advanced neuroimaging, we identified patterns associated with memory loss in […]
New Paper Published: Plasma S100β is a Predictor for Pathology and Cognitive Decline in Alzheimer’s Disease
This study highlights plasma S100β as a promising non-invasive biomarker for early detection and progression monitoring of Alzheimer’s disease. Given its strong association with cognitive decline and AD pathology, S100β could serve as a valuable diagnostic tool, addressing the urgent need for accessible biomarkers to guide early interventions and treatment strategies. View Publication
New Paper on Oxidative Stress in Isolated Brain Capillaries Published!
Neurovascular deficits and blood-brain barrier (BBB) dysfunction are major hallmarks of brain trauma and neurodegenerative diseases. Oxidative stress is a prominent contributor to neurovascular unit (NVU) dysfunction and can propagate BBB disruption. Oxidative damage results in an imbalance of mitochondrial homeostasis, which can further drive functional impairment of brain capillaries. To this end, we developed […]