New Paper on Oxidative Stress in Isolated Brain Capillaries Published!
Neurovascular deficits and blood-brain barrier (BBB) dysfunction are major hallmarks of brain trauma and neurodegenerative diseases. Oxidative stress is a prominent contributor to neurovascular unit (NVU) dysfunction and can propagate BBB disruption. Oxidative damage results in an imbalance of mitochondrial homeostasis, which can further drive functional impairment of brain capillaries. To this end, we developed […]
Louis’ Review on Glioblastoma Standard of Care is Published!
Glioblastoma is the most common and aggressive brain tumor in adults. Despite surgery, radiation, and chemotherapy, survival rates remain low, which emphasizes the urgent need for improved therapies. Current preclinical models use untreated tumors, which do not reflect the clinical scenario where patients already receive initial treatments. This review examines the effects of current treatments […]
Louis’ New Paper on Luciferase-Expressing Mouse Glioblastoma Models Published!
Inconsistent engraftment of luciferase-expressing tumors, especially GL261 Red-FLuc, has been reported in the recent literature. However, techniques to improve tumor take have not been described. Our study aimed to optimize two luciferase-expressing mouse glioblastoma models, GL261 Red-FLuc and TRP-mCherry-FLuc, which revealed differences in tumor development and characteristics. Congratulations Louis! View Publication
Graduation Party!
We celebrated Louis for completing his PhD, Tiffany for completing her PharmD/MS, and Jason for completing his MD. We are very proud of you and wish you the best of luck in your future endeavors!