Neurovascular deficits and blood-brain barrier (BBB) dysfunction are major hallmarks of brain trauma and neurodegenerative diseases. Oxidative stress is a prominent contributor to neurovascular unit (NVU) dysfunction and can propagate BBB disruption. Oxidative damage results in an imbalance of mitochondrial homeostasis, which can further drive functional impairment of brain capillaries. To this end, we developed a method to track mitochondrial-related changes after oxidative stress in the context of neurovascular pathophysiology as a critical endophenotype of neurodegenerative diseases.
BHL Team takes the Lexington Polar Plunge
We participated in the Polar Plunge to support Special Olympics Kentucky. Despite the cold conditions (outside temperature: 12°F; water temperature: 30°F), we joined other community participants to help raise funds and awareness for athletes with intellectual disabilities. The event provided an opportunity for the lab to contribute to a local
February 7, 2026
