Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance
We focus on Alzheimer’s disease (AD) animal models and their susceptibility to barrier leakage based on age and genetic background; on barrier dysfunction in clinical and postmortem studies; summarize changes that lead to barrier leakage in patients; and highlight the clinical relevance of barrier leakage in AD. We summarize signaling mechanisms that link barrier leakage […]