N-Acetylcysteine Attenuates Aβ-Mediated Oxidative Stress,Blood–Brain Barrier Leakage, and Renal Dysfunction in5xFAD Mice
Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) pathology andis closely linked to oxidative stress, which contributes to blood–brain barrier leakage,renal dysfunction, and cognitive decline. We investigated the effects of N-acetyl cysteine(NAC), an FDA-approved antioxidant, on oxidative stress, brain Aβ levels, barrier leakage,renal function, and cognition in 5xFAD mice. Eight-week-old 5xFAD mice were fed arodent […]