The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1
We show in brain capillaries of mice challenged with β-amyloid ex vivo that the level of the ubiquitin ligase Nedd4 increases concomitant with reduction in Abcb1. In vitro we show that human ABCB1 is a substrate for human NEDD4-1 ligase. Recombinant ABCB1 was purified from Sf21 insect cells and incubated with recombinant NEDD4-1 purified from […]