Targeting regulation of ABC Transporters at the Blood-Brain Barrier to improve Pharmacotherapy of CNS Disorders
The blood-brain barrier is the capillary endothelium between blood and brain that controls what goes in and comes out of the central nervous system (CNS). one major factor contributing to barrier function is a group of ATP-binding cassette (ABC) drug efflux transporters that restrict brain uptake of xenobiotics including a large number of CNS therapeutics. […]